Description

Buy Esketamine Nasal Spray
Ketamine nasal spray the drug is a form of ketamine, a generic drug that’s been use as a form of anesthesia for many years. Anand says.

Description

Ketamine has also been use for years in smaller doses in IV form for patients with treatment-resistant depression. But as a generic drug, it has not been put through the FDA’s review process for that use. Ketamine nasal spray

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It’s actually a controlled substance (it is sometimes abused as a recreational drug — you may have heard it called Special K).

Because of that, and because it can create feelings of dissociation and hallucination in people who take it, the new esketamine nasal spray will only be administer in a doctor’s office or hospital setting.

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A patient will go to their doctor once or twice a week to get nasal puffs of a dose of esketamine. Because they may experience disorientation or confusion immediately afterward, they will stay at the doctor’s office for two hours.

Esketamine nasal spray appears both effective and fast-acting for treatment-resistant depression,

Why is Ketamine nasal spray promising
One potential benefit of the new drug is that it’s fast-acting. People may notice a relief in symptoms within just a few hours, and it could last for several days. Most oral antidepressants, on the other hand, can take weeks to start working.

That’s because it works in a different way from other depression drugs. “Whereas most other available antidepressants work mainly on the serotonin, norepinephrine or dopamine systems, ketamine has major effects on glutamate, which is a different neurotransmitter that is much more prevalent in the brain,” Dr. Anand says.

Side Effects

Dizziness, dissociation, dysgeusia (change or distortion in sense of taste), vertigo, and nausea were the most common side effects of the drug. Most tended to occur shortly after dosing and cleared up within 90 minutes. However, the consensus of the study was that overall the drug was safe and tolerable.

An imperfect solution
Beyond potential side effects, ketamine does have additional drawbacks. Though it has been used safely as a short-term anesthetic and in lower doses as a short-term antidepressant,  don’t yet understand whether it’s safe and effective to use over long period.

Guarantee Of Esketamine nasal spray

There’s also no guarantee that it will work in all groups of people with treatment-resistant depression. And, like other antidepressants, there’s always the chance that it could make symptoms worse.

Esketamine was studied in five clinical trials leading up to its approval. Only one short-term trial, and its follow-up, longer-term relapse prevention trial of patients who had benefited from ketamine.  Produced positive results that were statistically significant.

Another study focused solely on adults over age 65,  found that benefit of treatment with antidepressants plus ketamine in that group of patients did not reach statistical significance.

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